Frequently Asked Questions
Browse answers to common questions about Inluriyo® + Verzenio®. Explore the list below to learn more. If you do not find the answer you are looking for, we recommend calling Lilly Support ServicesTM at 1-800-LillyRx or speaking directly with your healthcare provider.
About Inluriyo + Verzenio
Inluriyo (imlunestrant) and Verzenio (abemaciclib) are 2 prescription medications prescribed together to treat adults with ER+, HER2–, ESR1-mutated, advanced or metastatic breast cancer that progressed after endocrine therapy. Your healthcare provider will perform a test to make sure Inluriyo + Verzenio is right for you. It is not known if Inluriyo + Verzenio is safe and effective in children.
SELECT SAFETY SUMMARY
Most common side effects of Inluriyo when taken alone include decreased hemoglobin (anemia), muscle and joint pain, decreased white blood cell counts, increased liver function tests, decreased calcium blood levels, tiredness, diarrhea, increased triglyceride and cholesterol blood levels, nausea, decreased platelet counts, constipation, and stomach-area (abdominal) pain. These are not all the possible side effects of Inluriyo.
Most common side effects of Inluriyo when taken with abemaciclib include decreased white blood cell counts, diarrhea, decreased hemoglobin (anemia), nausea, decreased platelet counts, tiredness, increased triglyceride and cholesterol blood levels, infections, increased liver function tests, increased creatinine blood levels, vomiting, muscle and joint pain, stomach-area (abdominal) pain, decreased appetite, rash, cough, headache, and weight loss. These are not all the possible side effects of Inluriyo in combination with abemaciclib.
Your healthcare provider will check your blood levels, including monitoring your triglyceride and cholesterol blood levels, before and during treatment with Inluriyo.
Your healthcare provider may change your dose, temporarily stop, or completely stop treatment with Inluriyo if you develop certain side effects.
Inluriyo may affect fertility in males and in females who are able to become pregnant. Talk to your healthcare provider if this is a concern for you.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Verzenio may cause serious side effects, including diarrhea. Diarrhea is common with Verzenio, may be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. If you develop diarrhea during treatment, your healthcare provider may tell you to temporarily stop taking it, stop your treatment, or decrease your dose.
If you have any loose stools, start taking an antidiarrheal medicine (such as loperamide), drink more fluids, and tell your healthcare provider right away.
Most common side effects of Verzenio include diarrhea, infections, low white blood cell counts (neutropenia and leukopenia), tiredness (fatigue), stomach area (abdominal) pain, nausea, low red blood cell counts (anemia), and vomiting. These are not all the possible side effects of Verzenio.
Verzenio may cause fertility problems in males that may affect your ability to father a child.
Tell your healthcare provider if you have any side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Your healthcare provider may change your dose, temporarily stop, or completely stop treatment with Verzenio if you develop certain side effects.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Inluriyo and Verzenio and other medicines may affect each other, causing side effects. Keep a list of your current medications, vitamins, and supplements to show your healthcare provider or pharmacist when you get a new medicine. Especially tell your healthcare provider if you take a medicine that contains ketoconazole.
Call your doctor for medical advice about side effects.
Please see the Safety Summaries for Inluriyo and Verzenio at www.inluriyo.com, and the full Prescribing Information for Inluriyo and Verzenio.
ER+=estrogen receptor-positive; ESR1=estrogen receptor-1; HER2–=human epidermal growth factor receptor 2-negative
A blood test will determine if your ER+, HER2– metastatic breast cancer has an ESR1 mutation. The results of the blood test may help you and your doctor decide if Inluriyo (imlunestrant) + Verzenio (abemaciclib) is the right next treatment for you.
Learn more about testing for ESR1 mutations.
ER+=estrogen receptor-positive; ESR1=estrogen receptor-1; HER2–=human epidermal growth factor receptor 2-negative
Neither Inluriyo (imlunestrant) nor Verzenio (abemaciclib) is chemotherapy. Inluriyo is a targeted endocrine (hormone) treatment sometimes called an ER-antagonist. Verzenio is a CDK 4 & 6 inhibitor. Taken together, Inluriyo and Verzenio target the cancer in two different ways to block proteins inside cancer cells that help them divide and grow.
Inluriyo + Verzenio affects healthy cells and breast cancer cells, which can result in side effects, some of which can be serious.
ER+=estrogen receptor-positive; ESR1=estrogen receptor-1; HER2–=human epidermal growth factor receptor 2-negative
No, both Inluriyo (imlunestrant) and Verzenio (abemaciclib) are oral tablets that can be taken at home.
Results for Inluriyo + Verzenio
Inluriyo (imlunestrant) + Verzenio (abemaciclib) provided more time without disease progression than Inluriyo alone. In the trial, the median* time patients were alive without the cancer growing or spreading was 11.1 months with Inluriyo + Verzenio compared with 5.5 months with Inluriyo alone.
The comparison of Inluriyo + Verzenio to Inluriyo alone was planned as part of the study. The specific results shown here come from a smaller group of patients with an ESR1 mutation.
In the study, the measurement of disease progression included the growth and spread of cancer, or death from any cause.
Inluriyo + Verzenio was studied in a clinical trial of adults with ER+, HER2–, advanced or metastatic breast cancer that progressed after endocrine therapy. This analysis included 159 adults whose breast cancer had an ESR1 mutation. Of those with the mutation, 67 were treated with Inluriyo + Verzenio and 92 were treated with Inluriyo alone.
This comparison was not part of the study's original plan, and this finding comes from a less rigorous analysis that did not use statistical methods needed for confirmation.
Inluriyo + Verzenio showed a longer progression-free survival (PFS) compared with Inluriyo alone. PFS is how long a patient is alive without the cancer growing or spreading.
Learn more about the results of this study and how it was conducted.
*The median is the middle number in a range of numbers.
SELECT SAFETY SUMMARY
Most common side effects of Inluriyo when taken alone include decreased hemoglobin (anemia), muscle and joint pain, decreased white blood cell counts, increased liver function tests, decreased calcium blood levels, tiredness, diarrhea, increased triglyceride and cholesterol blood levels, nausea, decreased platelet counts, constipation, and stomach-area (abdominal) pain. These are not all the possible side effects of Inluriyo.
Most common side effects of Inluriyo when taken with abemaciclib include decreased white blood cell counts, diarrhea, decreased hemoglobin (anemia), nausea, decreased platelet counts, tiredness, increased triglyceride and cholesterol blood levels, infections, increased liver function tests, increased creatinine blood levels, vomiting, muscle and joint pain, stomach-area (abdominal) pain, decreased appetite, rash, cough, headache, and weight loss. These are not all the possible side effects of Inluriyo in combination with abemaciclib.
Your healthcare provider will check your blood levels, including monitoring your triglyceride and cholesterol blood levels, before and during treatment with Inluriyo.
Your healthcare provider may change your dose, temporarily stop, or completely stop treatment with Inluriyo if you develop certain side effects.
Inluriyo may affect fertility in males and in females who are able to become pregnant. Talk to your healthcare provider if this is a concern for you.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Verzenio may cause serious side effects, including diarrhea. Diarrhea is common with Verzenio, may be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. If you develop diarrhea during treatment, your healthcare provider may tell you to temporarily stop taking it, stop your treatment, or decrease your dose.
If you have any loose stools, start taking an antidiarrheal medicine (such as loperamide), drink more fluids, and tell your healthcare provider right away.
Most common side effects of Verzenio include diarrhea, infections, low white blood cell counts (neutropenia and leukopenia), tiredness (fatigue), stomach area (abdominal) pain, nausea, low red blood cell counts (anemia), and vomiting. These are not all the possible side effects of Verzenio.
Verzenio may cause fertility problems in males that may affect your ability to father a child.
Tell your healthcare provider if you have any side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Your healthcare provider may change your dose, temporarily stop, or completely stop treatment with Verzenio if you develop certain side effects.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Inluriyo and Verzenio and other medicines may affect each other, causing side effects. Keep a list of your current medications, vitamins, and supplements to show your healthcare provider or pharmacist when you get a new medicine. Especially tell your healthcare provider if you take a medicine that contains ketoconazole.
Call your doctor for medical advice about side effects.
Please see the Safety Summaries for Inluriyo and Verzenio at www.inluriyo.com, and the full Prescribing Information for Inluriyo and Verzenio.
ER+=estrogen receptor-positive; ESR1=estrogen receptor-1; HER2–=human epidermal growth factor receptor 2-negative; PFS=progression-free survival
Savings & Support
From the start of treatment, the Inluriyo (imlunestrant) Savings Card and Verzenio (abemaciclib) Savings Card are available to help with out-of-pocket expenses if you are eligible and commercially insured with coverage for Inluriyo and Verzenio. Governmental beneficiaries excluded, terms and conditions apply.
Lilly Support Services™ aims to offer support for eligible patients prescribed Lilly's cancer treatments, including Inluriyo (imlunestrant) and Verzenio (abemaciclib) together. Those who qualify can get help with understanding insurance coverage, reviewing financial assistance options, and more.
If you have questions about Lilly Support Services for Inluriyo and Lilly Support Services for Verzenio, please call 1-800-LillyRx (1-800-545-5979) from Monday to Friday.
Dosing & Administration
Medication
InluriyoDose
2 tablets
Frequency
Once daily
How to Take It
Take at about the same time every day as directed by your healthcare provider
Take on an empty stomach—at least 2 hours before food or 1 hour after food
Medication
VerzenioDose
1 tablet
Frequency
Twice daily (AM & PM)
How to Take It
Take at about the same time every day as directed by your healthcare provider
You may take 1 Verzenio dose at the same time as your daily Inluriyo dose (on an empty stomach)
When the Verzenio tablet is taken alone, it may be taken with or without food
Avoid grapefruit products
Additional InformationSwallow tablets whole. Do not split, crush, or chew tablets.
Your healthcare provider may change or stop your dose if needed. Do not stop taking Inluriyo + Verzenio or change your dose unless instructed to do so by your healthcare provider.
If you miss a dose or vomit after taking a dose, do not take another dose to make up for the missed or vomited dose. Do not take 2 doses at the same time to make up for a missed dose. Take your next dose at your regularly scheduled time.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Inluriyo, Verzenio, and/or certain other medicines can affect each other, causing serious side effects or changing the effect of Inluriyo, Verzenio, and/or other medicines. Your healthcare provider may need to change your dose.
TIP: Keeping a daily log or setting a phone reminder for each dose can help you remember to take your medication on time.
Store Inluriyo and Verzenio at room temperature between 68°F to 77°F (20°C to 25°C). Keep Inluriyo, Verzenio, and all medicines out of the reach of children.
Take Inluriyo (imlunestrant) on an empty stomach, at least 2 hours before food or 1 hour after food.
When the Verzenio (abemaciclib) tablet is taken alone, it may be taken with or without food.
Yes, Inluriyo (imlunestrant) + Verzenio (abemaciclib) can be taken while away from home but must be stored at room temperature between 68°F to 77°F (20°C to 25°C). Keep Inluriyo, Verzenio, and all medicines out of the reach of children.
Safety & Side Effects
SELECT SAFETY SUMMARY
Most common side effects of Inluriyo when taken alone include decreased hemoglobin (anemia), muscle and joint pain, decreased white blood cell counts, increased liver function tests, decreased calcium blood levels, tiredness, diarrhea, increased triglyceride and cholesterol blood levels, nausea, decreased platelet counts, constipation, and stomach-area (abdominal) pain. These are not all the possible side effects of Inluriyo.
Most common side effects of Inluriyo when taken with abemaciclib include decreased white blood cell counts, diarrhea, decreased hemoglobin (anemia), nausea, decreased platelet counts, tiredness, increased triglyceride and cholesterol blood levels, infections, increased liver function tests, increased creatinine blood levels, vomiting, muscle and joint pain, stomach-area (abdominal) pain, decreased appetite, rash, cough, headache, and weight loss. These are not all the possible side effects of Inluriyo in combination with abemaciclib.
Your healthcare provider will check your blood levels, including monitoring your triglyceride and cholesterol blood levels, before and during treatment with Inluriyo.
Your healthcare provider may change your dose, temporarily stop, or completely stop treatment with Inluriyo if you develop certain side effects.
Inluriyo may affect fertility in males and in females who are able to become pregnant. Talk to your healthcare provider if this is a concern for you.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Verzenio may cause serious side effects, including diarrhea. Diarrhea is common with Verzenio, may be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. If you develop diarrhea during treatment, your healthcare provider may tell you to temporarily stop taking it, stop your treatment, or decrease your dose.
If you have any loose stools, start taking an antidiarrheal medicine (such as loperamide), drink more fluids, and tell your healthcare provider right away.
Most common side effects of Verzenio include diarrhea, infections, low white blood cell counts (neutropenia and leukopenia), tiredness (fatigue), stomach area (abdominal) pain, nausea, low red blood cell counts (anemia), and vomiting. These are not all the possible side effects of Verzenio.
Verzenio may cause fertility problems in males that may affect your ability to father a child.
Tell your healthcare provider if you have any side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Your healthcare provider may change your dose, temporarily stop, or completely stop treatment with Verzenio if you develop certain side effects.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Inluriyo and Verzenio and other medicines may affect each other, causing side effects. Keep a list of your current medications, vitamins, and supplements to show your healthcare provider or pharmacist when you get a new medicine. Especially tell your healthcare provider if you take a medicine that contains ketoconazole.
Call your doctor for medical advice about side effects.
Please see the Safety Summaries for Inluriyo and Verzenio at www.inluriyo.com, and the full Prescribing Information for Inluriyo and Verzenio.
Your healthcare provider will check your blood levels, including monitoring your triglyceride and cholesterol blood levels, before and during treatment with Inluriyo (imlunestrant).
Muscle or joint pain and diarrhea can occur while taking Inluriyo + Verzenio.
Tell your healthcare provider about all of the side effects you may experience. Your healthcare provider may be able to manage certain side effects.
Do not stop taking Inluriyo or Verzenio, or change your dose unless instructed to do so by your healthcare provider.
To learn more about side effects for Inluriyo and Verzenio, please see their Safety Summaries at www.inluriyo.com, and the full Prescribing Information for Inluriyo and Verzenio.
Before taking Inluriyo (imlunestrant) + Verzenio (abemaciclib), tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Inluriyo and Verzenio and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine. For detailed information on how to take Inluriyo and Verzenio, click here.
Talk to your healthcare provider before receiving a vaccine to discuss your specific health situation and treatment plan.